The authors evaluated endometrial cancer risk associations of 84 foods and nutrients based on dietary questionnaires in three prospective studies: the European Prospective Investigation into Cancer and Nutrition (EPIC) with 1,303 cases, followed by validation of nine foods/nutrients in the Nurses’ Health Studies (NHS/NHSII) with 1,531 cases. Cox regression models were used to estimate HRs and 95% confidence intervals (CI).
In the comparisons of the extreme categories of intake, coffee was found to be inversely associated with endometrial cancer risk (median intake 750 g/day – 8.6 and median intake 1067 g/day – 0). Eight other dietary factors (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were associated with endometrial cancer risk in the EPIC study, but were not confirmed in the NHS/NHSII. They recommend that extra and more detailed data are needed to confirm these research findings and to examine the mechanisms linking coffee intake to endometrial cancer risk in order to develop prevention strategies.